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Life Extension of
Canelim Capsules on H22 tumor-bearing mice
Yuan B. Xiang et al., Xian Medical University
Result (3
tests):
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|
Cases
|
Dosage
|
Body weight  |
Survival days |
Life extension
|
|
(mg/kg)
|
before
|
|
(d)
|
rate(%)
|
|
Test 1
|
|
Normal control
|
10
|
--
|
18.9 ¡À 1.3
|
26.1 ¡À 2.9
|
>40
|
|
|
H22 control
|
10
|
--
|
19.0 ¡À 1.2
|
30.4 ¡À 3.8
|
8.9 ¡À 2.0
|
|
|
Canelim
|
11
|
100
|
19.3 ¡À 1.1
|
34.1 ¡À 6.3
|
11.0 ¡À 1.8
|
23.6
|
|
|
12
|
200
|
19.2 ¡À 1.0
|
27.7 ¡À 5.1
|
13.7 ¡À 6.7*
|
53.9
|
|
|
12
|
400
|
19.2 ¡À 1.3
|
34.9 ¡À 7.8
|
17.0 ¡À 7.8**
|
91.0
|
|
Test 2
|
|
Normal control
|
10
|
--
|
19.2 ¡À 1.3
|
27.2 ¡À 2.6
|
>40
|
|
|
H22 control
|
10
|
--
|
18.5 ¡À 0.9
|
32.5 ¡À 3.3
|
9.0 ¡À 1.5
|
|
|
Canelim
|
10
|
100
|
19.1 ¡À 1.0
|
32.1 ¡À 6.0
|
10.5 ¡À 1.6
|
16.7
|
|
|
10
|
200
|
18.5 ¡À 0.7
|
34.1 ¡À 6.5
|
11.4 ¡À 1.3*
|
26.7
|
|
|
10
|
400
|
19.6 ¡À 0.7
|
32.7 ¡À 7.0
|
12.2 ¡À 2.7*
|
35.6
|
|
Test 3
|
|
Normal control
|
10
|
--
|
18.6 ¡À 0.8
|
25.0 ¡À 1.2
|
>40
|
|
|
H22 control
|
10
|
--
|
19.6 ¡À 0.7
|
33.1 ¡À 2.3
|
8.5 ¡À 1.6
|
|
|
Canelim
|
11
|
100
|
18.5 ¡À 0.7
|
34.7 ¡À 2.9
|
11.0 ¡À 7.5
|
29.4
|
|
|
12
|
200
|
18.2 ¡À 0.4
|
35.5 ¡À 4.5
|
11.7 ¡À 2.3*
|
37.6
|
|
|
|
|
|
|
|
|
 compared
with H22 tumor control group, * means p<0.05, ** means
p<0.01
Discuss:
The life exttension rate
differs with the dosage of Canelim Capsules. When compared
with H22 tumor control group, the difference is significant
in the middle and large dosage group (p<0.05, p<0.01).
With the large doseage(0.4 g/kg),
the survival rate extended attains to 36% to 91% respectively.
Conclusion£º
Canelim Capsules can
inhibit the tumor and significantly extend survival
period of H22 tumor- bearing mice.
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