|
Tumor inhibition
of Canelim Capsules on S180 tumor-bearing mice
Yuan B. Xiang et al., Xian Medical University
Result (3
tests):
|
Group
|
Cases
|
Dosage
|
Body Weight (g)  |
Tumor weight
|
Inhibition Rate
|
|
n
|
(mg/kg)
|
before treatment
|
after treatment
|
(g)
|
(%)
|
|
Test 1
|
|
Normal Control
|
10
|
--
|
20.1 ¡À 1.1
|
24.2 ¡À 1.9**
|
|
|
|
S180 Control
|
10
|
--
|
19.1 ¡À 1.2
|
30.9 ¡À 3.2
|
|
|
|
Canelim
|
10
|
100
|
19.1 ¡À 1.3
|
29.0 ¡À 3.4
|
0.64 ¡À 0.31**
|
84.9
|
|
|
10
|
200
|
18.9 ¡À 0.9
|
29.7 ¡À 6.8
|
0.49 ¡À 0.17**
|
88.5
|
|
|
10
|
400
|
18.1 ¡À 0.3
|
28.1 ¡À 3.7**
|
0.36 ¡À 0.18**
|
91.5
|
|
Test 2
|
|
Normal Control
|
10
|
--
|
19.9 ¡À 2.0
|
27.1 ¡À 2.7**
|
|
|
|
S180 Control
|
10
|
--
|
20.6 ¡À 2.2
|
30.1 ¡À 1.6
|
2.76 ¡À 1.10
|
|
|
Canelim
|
10
|
100
|
20.1 ¡À 2.0
|
31.1 ¡À 2.0
|
1.64 ¡À 0.75**
|
35.1
|
|
|
10
|
200
|
20.1 ¡À 1.3
|
30.7 ¡À 3.0
|
1.78 ¡À 0.38**
|
35.5
|
|
|
10
|
400
|
1.86 ¡À 1.3
|
26.3 ¡À 3.5**
|
1.79 ¡À 0.59**
|
40.6
|
|
Test 3
|
|
Normal Control
|
10
|
--
|
18.7 ¡À 0.9
|
26.4 ¡À 2.4
|
|
|
|
S180 Control
|
10
|
--
|
18.2 ¡À 0.4
|
28.7 ¡À 7.5
|
2.26 ¡À 0.67
|
|
|
Canelim
|
10
|
100
|
20.0 ¡À 1.3
|
26.1 ¡À 3.2
|
0.74 ¡À 0.44**
|
59.3
|
|
|
10
|
200
|
20.9 ¡À 1.4
|
26.3 ¡À 4.1
|
0.79 ¡À 0.34**
|
65.0
|
|
|
10
|
400
|
19.5 ¡À 1.5
|
23.1 ¡À 3.8*
|
0.86 ¡À 0.41**
|
67.3
|
 compared
with S180 tumor control group, * means p<0.05, **
means p<0.01
Discuss:
a. Tumor weight decreased
greatly after the administration of Canelim Capsules
(0.1-0.4 g/kg), compared with the tumor control group,
the difference is significant. The inhibition rate is
between 35% and 85%
b. The weight of S180 tumor-bearing mice decreased slightly,
but it remains in the normal range.
Conclusion
Canelim Capsules can significantly
kill S180 tumor cells and shrink, inhibit it from further
development.
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